Soluble ST2 predicts outcome and hemorrhagic transformation after acute stroke

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Soluble ST2 predicts outcome and hemorrhagic transformation after acute stroke

OBJECTIVE ST2 is a member of the toll-like receptor superfamily that can alter inflammatory signaling of helper T-cells. We investigated whether soluble ST2 (sST2) could independently predict outcome and hemorrhagic transformation (HT) in the setting of stroke. METHODS We measured sST2 in patients enrolled in the Specialized Program of Translational Research in Acute Stroke (SPOTRIAS) network...

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Plasma cellular-fibronectin concentration predicts hemorrhagic transformation after thrombolytic therapy in acute ischemic stroke.

BACKGROUND AND PURPOSE Elevated plasma levels of cellular fibronectin (c-Fn) reflect vascular damage, so c-Fn might be a marker of secondary bleeding risk in cerebral ischemia. We investigated whether high plasma levels of c-Fn were associated with hemorrhagic transformation (HT) after treatment with tissue plasminogen activator (tPA) in patients with acute stroke. METHODS Eighty-seven patien...

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Use of Antithrombotics after Hemorrhagic Transformation in Acute Ischemic Stroke

BACKGROUNDS There have been neither appropriate guidelines nor clinical studies about the use of antithrombotics after hemorrhagic transformation (HT). We sought to find whether the use of antithrombotics after hemorrhagic infarction might be associated with aggravation of HT and neurological deterioration. METHODS This retrospective study included prospectively registered consecutive patient...

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Predicting Hemorrhagic Transformation of Acute Ischemic Stroke

Hemorrhagic transformation (HT) increases the morbidity and mortality of ischemic stroke. Anticoagulation is often indicated in patients with atrial fibrillation, low ejection fraction, or mechanical valves who are hospitalized with acute stroke, but increases the risk of HT. Risk quantification would be useful. Prior studies have investigated risk of systemic hemorrhage in anticoagulated patie...

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Plasma metalloproteinase-9 concentration predicts hemorrhagic transformation in acute ischemic stroke.

BACKGROUND AND PURPOSE Matrix metalloproteinase-9 (MMP-9) activity has been associated with hemorrhagic transformation (HT) in experimental models of cerebral ischemia. Our aim was to investigate the relationship between MMP-9 concentrations in blood within 24 hours of stroke onset and subsequent HT of cerebral infarction. METHODS We studied 250 patients with a hemispheric ischemic stroke of ...

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ژورنال

عنوان ژورنال: Annals of Clinical and Translational Neurology

سال: 2017

ISSN: 2328-9503

DOI: 10.1002/acn3.435